大阪大学大学院医学系研究科保健学専攻生体情報科学講座 心血管代謝学研究室

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業績集

原著論文2011年以降

  1. Yamamoto H, Tanaka Y, Sawada M, Kihara S. ERRα Attenuates Vascular Inflammation via Enhanced NFκB Degradation Pathway. Endocrinology 164(3): bqac212, 2023
  2. Yamamoto H, Yoshida N, Kihara S. Esaxerenone Blocks Vascular Endothelial Inflammation Through SGK1. J Cardiovasc Pharmacol. 80(4): 583-591, 2022
  3. Imai M, Kawamura M, Kochi I, Matsuoka T, Kihara S, Yamamoto H. Anti-Apo B-100 Autoantibody is a Marker of Unstable Coronary Plaque. J Atheroscler Thromb. 28(10): 1025-1034, 2021
  4. Uekita H, Yamamoto H, Niinaga R, Yamane N, Yoshii M, Yamauchi-Takihara K, Kihara S. Reciprocal association of serum Mac-2 binding protein and HDL-cholesterol concentrations. Clin Chim Acta. 516: 142-148, 2021
  5. Fujita M, Yamamoto H, Yoshida N, Ono R, Matsuoka T, Kihara S. Atheroprotective Roles of Adiponectin via CCL2 Inhibition. J Atheroscler Thromb. 28(11): 1204-1213, 2021
  6. Kawai T, Kayama K, Tatsumi S, Akter S, Miyawaki N, Okochi Y, Abe M, Sakimura K, Yamamoto H, Kihara S, Okamura Y. Regulation of hepatic oxidative stress by voltage-gated proton channels (Hv1/VSOP) in Kupffer cells and its potential relationship with glucose metabolism. FASEB J. 34(12): 15805-15821, 2020
  7. Imai M, Yamamoto H, Hashimoto T, Koyama H, Kihara S. Acquired marked hypertriglyceridemia with anti-GPIHBP1 antibodies. Pediatr Int. 62(5): 651-653, 2020
  8. Sawada M, Yamamoto H, Ogasahara A, Tanaka Y, Kihara S.　β-aminoisobutyric acid protects against vascular inflammation through PGC-1β-induced antioxidative properties.Biochem Biophys Res Commun. 516(3): 963-968, 2019
  9. Yamamoto H, Kawamura M, Kochi I, Imai M, Murata Y, Suzuki T, Chen Y, Hashimoto K, Kihara S. Serum Anti-Apo B Antibody Level as Residual CVD Marker in DM Patients under Statin Treatment. J Atheroscler Thromb. 26(10): 931-943, 2019
  10. Inoue M, Kawamura M, Yamamoto H, Takahashi T, Kihara S. Juvenile-onset systemic lupus erythematosus with severe hypertriglyceridemia induced by anti-apolipoprotein C-II antibody. Pediatr Int. 61(2): 201-203, 2019
  11. Nojiri T, Kurano M, Araki O, Nakawatari K, Nishikawa M, Shimamoto S, Igarashi K, Kano K, Aoki J, Kihara S, Murakami M, Yatomi Y. Serum autotaxin levels are associated with Graves' disease. Endocr J. 66(5):409-422, 2019
  12. Masuda D, Kobayashi T, Sairyou M, Hanada H, Ohama T, Koseki M, Nishida M, Maeda N, Kihara S, Minami T, Yanagi K, Sakata Y, Yamashita S. Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial). J Atheroscler Thromb. 25(6), 512-520, 2018
  13. Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y. Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1). Channels (Austin). 12(1), 1-8, 2018
  14. Matsumoto A, Yamamoto H, Matsuoka T, Kayama K, Onishi S, Matsuo N, Kihara S. Cystatin C-Adiponectin Complex in Plasma Associates with Coronary Plaque Instability. J Atheroscler Thromb. 24(9): 970-979, 2017
  15. Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y. Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1). Channels (Austin). 12(1): 1-8, 2018
  16. Michikura M, Ogura M, Yamamoto M, Sekimoto M, Fuke C, Hori M, Arai K, Kihara S, Hosoda K, Yanagi K, Harada-Shiba M. Achilles Tendon Ultrasonography for Diagnosis of Familial Hypercholesterolemia Among Japanese Subjects. Circ J. 81(12): 1879-1885, 2017
  17. Matsuo K, Shibata R, Ohashi K, Kambara T, Uemura Y, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Ito M, Hayakawa S, Ogawa H, Kihara S, Murohara T, Ouchi N. Omentin functions to attenuate cardiac hypertrophic response. J Mol Cell Cardiol. 79:195-202, 2015
  18. Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T, Ouchi N. Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice. Cardiovasc Res. 110(1): 107-117, 2016
  19. Niinaga R, Yamamoto H, Yoshii M, Uekita H, Yamane N, Kochi I, Matsumoto A, Matsuoka T, Kihara S. Marked elevation of serum M2BP-adiponectin complex in men with coronary artery disease. Atherosclerosis. 253:70-74, 2016.
  20. Yamamoto H, Kuroda N, Uekita H, Kochi I, Matsumoto A, Niinaga R, Funahashi T, Shimomura I, Kihara S. E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion. Biochem Biophys Res Commun. 2016 Feb 5;470(2):425-30.
  21. Matsuo N, Matsuoka T, Onishi S, Yamamoto H, Kato A, Makino Y, Kihara S. Impact of Remnant Lipoprotein on Coronary Plaque Components. J Atheroscler Thromb. 2015 Aug 26;22(8):783-95.
  22. Yamamoto H, Tanaka M, Yoshiga S, Funahashi T, Shimomura I, Kihara S. Autoimmune severe hypertriglyceridemia induced by anti-apolipoprotein C-II antibody.　J Clin Endocrinol Metab. 99(5):1525-1530, 2014
  23. Ryo M, Funahashi T, Nakamura T, Kihara S, Kotani K, Tokunaga K, Matsuzawa Y, Shimomura I.　Fat accumulation and obesity-related cardiovascular risk factors in middle-aged Japanese men and women. Intern Med. 53(4): 299-305, 2014
  24. Nakatsuji H, Kishida K, Sekimoto R, Komura N, Kihara S, Funahashi T, Shimomura I. Accumulation of adiponectin in inflamed adipose tissues of obese mice.　Metabolism. 63(4):542-553, 2014
  25. Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N. Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema. J Am Heart Assoc. 2013 Sep 19; 2(5):e000438.
  26. Komura N, Maeda N, Mori T, Kihara S, Nakatsuji H, Hirata A, Tochino Y, Funahashi T, Shimomura I. Adiponectin protein exists in aortic endothelial cells.　PLoS One 2013 Aug 13; 8(8): e71271.
  27. Yamamoto H, Onishi M, Miyamoto N, Oki R, Ueda H, Ishigami M, Hiraoka H, Matsuzawa Y, Kihara S. Novel combined GPIHBP1 mutations in a patient with hypertriglyceridemia associated with CAD.　J Atheroscler Thromb. 20(10): 777-784, 2013
  28. Hu D, Fukuhara A, Miyata Y, Yokoyama C, Otsuki M, Kihara S, Shimomura I. Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway.　PLoS One 8(2): e56071, 2013
  29. Okamoto Y, Ishii S, Croce K, Katsumata H, Fukushima M, Kihara S, Libby P, Minami S. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques.　Atherosclerosis. 226(2): 373-377, 2013
  30. Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K. LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest. 122(8): 2817-2826, 2012
  31. Shibata R, Ouchi N, Takahashi R, Terakura Y, Ohashi K, Ikeda N, Higuchi A, Terasaki H, Kihara S, Murohara T. Omentin as a novel biomarker of metabolic risk factors.　Diabetol Metab Syndr. 26; 4(1): 37, 2012
  32. Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 15(6): 838-847, 2012
  33. Yamamoto S, Watabe K, Araki H, Kamada Y, Kato M, Kizu T, Kiso S, Tsutsui S, Tsujii M, Kihara S, Funahashi T, Shimomura I, Hayashi N, Takehara T.　Protective role of adiponectin against ethanol-induced gastric injury in mice.　Am J Physiol Gastrointest Liver Physiol. 302(8): G773-780, 2012
  34. Fernandez-Marcos PJ, Jeninga EH, Canto C, Harach T, de Boer VC, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten SM, Schoonjans K, Auwerx J. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep. 2012; 2: 425.
  35. Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N.　Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism. J Biol Chem. 287(1): 408-417, 2012
  36. Shibata R, Ouchi N, Kikuchi R, Takahashi R, Takeshita K, Kataoka Y, Ohashi K, Ikeda N, Kihara S, Murohara T. Circulating omentin is associated with coronary artery disease in men.　Atherosclerosis. 219(2): 811-814, 2011
  37. Kato M, Watabe K, Hamasaki T, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Yamamoto S, Kamada Y, Yoshida Y, Kiso S, Tsutsui S, Kihara S, Hayashi N, Matsuzawa Y.　Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups.　J Gastroenterol. 46(12): 1361-1367, 2011
  38. Shibata R, Takahashi R, Kataoka Y, Ohashi K, Ikeda N, Kihara S, Murohara T, Ouchi N.　Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men.　Hypertens Res. 34(12): 1309-1312, 2011
  39. Yamamoto H, Williams EG, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell. 147(4): 827-839, 2011
  40. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell. 147(4): 815-826, 2011
  41. Beirowski B, Gustin J, Armour SM,Yamamoto H, Viader A, North BJ, Michan S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 108(43): E952-961, 2011
  42. Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 12(10): 1069-1076, 2011
  43. Yamamoto S, Watabe K, Tsutsui S, Kiso S, Hamasaki T, Kato M, Kamada Y, Yoshida Y, Kihara S, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Hayashi N, Matsuzawa Y.　Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis.　Dig Dis Sci. 56(8): 2354-2360, 2011
  44. Hiuge-Shimizu A, Maeda N, Hirata A, Nakatsuji H, Nakamura K, Okuno A, Kihara S, Funahashi T, Shimomura I. Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone.　Arterioscler Thromb Vasc Biol. 31(4): 792-799, 2011
  45. Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13(4): 461-468, 2011
  46. Bai P, Canto C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J. PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab. 13(4): 450-460, 2011
  47. Nakagawa Y, Kishida K, Kihara S, Yoshida R, Funahashi T, Shimomura I.　Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue. J Atheroscler Thromb. 18(3): 240-247, 2011
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