大阪大学大学院医学系研究科保健学専攻生体情報科学講座 心血管代謝学研究室

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業績集

原著論文2011年以降

  1. Imai M, Kawamura M, Kochi I, Matsuoka T, Kihara S, Yamamoto H. Anti-apo B-100 autoantibody is a marker of unstable coronary plaque. J Atheroscler Thromb. 2020 in press
  2. Fujita M, Yamamoto H, Yoshida N, Ono R, Matsuoka T, Kihara S. Atheroprotective roles of adiponectin via CCL2 inhibition. J Atheroscler Thromb. 2020 in press
  3. Imai M, Yamamoto H, Hashimoto T, Koyama H, Kihara S. Acquired marked hypertriglyceridemia with anti-GPIHBP1 antibodies. Pediatr Int. 2020 May; 62(5): 651-653
  4. Sawada M, Yamamoto H, Ogasahara A, Tanaka Y, Kihara S. β-aminoisobutyric acid protects against vascular inflammation through PGC-1β-induced antioxidative properties. Biochem Biophys Res Commun. 2019 Aug 27; 516(3): 963-968.
  5. Yamamoto H, Kawamura M, Kochi I, Imai M, Murata Y, Suzuki T, Chen Y, Hashimoto K, Kihara S. Serum Anti-Apo B Antibody Level as Residual CVD Marker in DM Patients under Statin Treatment. J Atheroscler Thromb. 2019 Oct 1;26(10):931-943
  6. Inoue M, Kawamura M, Yamamoto H, Takahashi T, Kihara S. Juvenile-onset systemic lupus erythematosus with severe hypertriglyceridemia induced by anti-apolipoprotein C-II antibody. Pediatr Int. 2019 Feb;61(2):201-203
  7. Nojiri T, Kurano M, Araki O, Nakawatari K, Nishikawa M, Shimamoto S, Igarashi K, Kano K, Aoki J, Kihara S, Murakami M, Yatomi Y. Serum autotaxin levels are associated with Graves' disease. Endocr J. 2019 May 28;66(5):409-422
  8. Masuda D, Kobayashi T, Sairyou M, Hanada H, Ohama T, Koseki M, Nishida M, Maeda N, Kihara S, Minami T, Yanagi K, Sakata Y, Yamashita S. Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial). J Atheroscler Thromb. 25(6), 512-520, 2018
  9. Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y. Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1). Channels (Austin). 12(1), 1-8, 2018
  10. Matsumoto A, Yamamoto H, Matsuoka T, Kayama K, Onishi S, Matsuo N, Kihara S. Cystatin C-Adiponectin Complex in Plasma Associates with Coronary Plaque Instability. J Atheroscler Thromb. 2017 Sep 1; 24(9): 970-979
  11. Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y. Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1). Channels (Austin). 2018 Jan 1; 12(1): 1-8
  12. Michikura M, Ogura M, Yamamoto M, Sekimoto M, Fuke C, Hori M, Arai K, Kihara S, Hosoda K, Yanagi K, Harada-Shiba M. Achilles Tendon Ultrasonography for Diagnosis of Familial Hypercholesterolemia Among Japanese Subjects. Circ J. 2017 Nov 24; 81(12): 1879-1885
  13. Matsuo K, Shibata R, Ohashi K, Kambara T, Uemura Y, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Ito M, Hayakawa S, Ogawa H, Kihara S, Murohara T, Ouchi N. Omentin functions to attenuate cardiac hypertrophic response. J Mol Cell Cardiol. 2015;79:195-202
  14. Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T, Ouchi N. Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice. Cardiovasc Res. 110(1): 107-117, 2016
  15. Niinaga R, Yamamoto H, Yoshii M, Uekita H, Yamane N, Kochi I, Matsumoto A, Matsuoka T, Kihara S. Marked elevation of serum M2BP-adiponectin complex in men with coronary artery disease. Atherosclerosis. 2016 Oct;253:70-74.
  16. Yamamoto H, Kuroda N, Uekita H, Kochi I, Matsumoto A, Niinaga R, Funahashi T, Shimomura I, Kihara S. E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion. Biochem Biophys Res Commun. 2016 Feb 5;470(2):425-30.
  17. Matsuo N, Matsuoka T, Onishi S, Yamamoto H, Kato A, Makino Y, Kihara S. Impact of Remnant Lipoprotein on Coronary Plaque Components. J Atheroscler Thromb. 2015 Aug 26;22(8):783-95.
  18. Yamamoto H, Tanaka M, Yoshiga S, Funahashi T, Shimomura I, Kihara S. Autoimmune severe hypertriglyceridemia induced by anti-apolipoprotein C-II antibody. J Clin Endocrinol Metab. 2014 Feb 25:jc20133619. [Epub ahead of print]
  19. Ryo M, Funahashi T, Nakamura T, Kihara S, Kotani K, Tokunaga K, Matsuzawa Y, Shimomura I. Fat accumulation and obesity-related cardiovascular risk factors in middle-aged Japanese men and women. Intern Med. 2014; 53(4): 299-305.
  20. Nakatsuji H, Kishida K, Sekimoto R, Komura N, Kihara S, Funahashi T, Shimomura I. Accumulation of adiponectin in inflamed adipose tissues of obese mice. Metabolism. 2014 Apr; 63(4):542-553. doi: 10.1016/j.metabol.2013.12.012.
  21. Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N. Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema. J Am Heart Assoc. 2013 Sep 19; 2(5):e000438. doi: 10.1161/JAHA.113.000438.
  22. Komura N, Maeda N, Mori T, Kihara S, Nakatsuji H, Hirata A, Tochino Y, Funahashi T, Shimomura I. Adiponectin protein exists in aortic endothelial cells. PLoS One 2013 Aug 13; 8(8): e71271. doi: 10.1371/journal.pone.0071271. eCollection 2013.
  23. Yamamoto H, Onishi M, Miyamoto N, Oki R, Ueda H, Ishigami M, Hiraoka H, Matsuzawa Y, Kihara S. Novel combined GPIHBP1 mutations in a patient with hypertriglyceridemia associated with CAD. J Atheroscler Thromb. 2013; 20(10): 777-784.
  24. Hu D, Fukuhara A, Miyata Y, Yokoyama C, Otsuki M, Kihara S, Shimomura I. Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway. PLoS One 2013; 8(2): e56071. doi: 10.1371/journal.pone.0056071.
  25. Okamoto Y, Ishii S, Croce K, Katsumata H, Fukushima M, Kihara S, Libby P, Minami S. Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques. Atherosclerosis. 2013 Feb; 226(2): 373-377. doi: 10.1016/j.atherosclerosis.2012.12.012.
  26. Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K. LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest. 2012 Aug 1; 122(8): 2817-2826
  27. Shibata R, Ouchi N, Takahashi R, Terakura Y, Ohashi K, Ikeda N, Higuchi A, Terasaki H, Kihara S, Murohara T. Omentin as a novel biomarker of metabolic risk factors. Diabetol Metab Syndr. 2012 Jul 26; 4(1): 37. doi: 10.1186/1758-5996-4-37.
  28. Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6; 15(6): 838-847.
  29. Yamamoto S, Watabe K, Araki H, Kamada Y, Kato M, Kizu T, Kiso S, Tsutsui S, Tsujii M, Kihara S, Funahashi T, Shimomura I, Hayashi N, Takehara T. Protective role of adiponectin against ethanol-induced gastric injury in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15; 302(8): G773-780. doi: 1152/ajpgi.00324.2011.
  30. Fernandez-Marcos PJ, Jeninga EH, Canto C, Harach T, de Boer VC, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten SM, Schoonjans K, Auwerx J. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep. 2012; 2: 425.
  31. Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N. Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism. J Biol Chem. 2012 Jan 2; 287(1): 408-417. doi: 10.1074/jbc.M111.261818.
  32. Shibata R, Ouchi N, Kikuchi R, Takahashi R, Takeshita K, Kataoka Y, Ohashi K, Ikeda N, Kihara S, Murohara T. Circulating omentin is associated with coronary artery disease in men. Atherosclerosis. 2011 Dec; 219(2): 811-814. doi: 10.1016/j.atherosclerosis.2011.08.017.
  33. Kato M, Watabe K, Hamasaki T, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Yamamoto S, Kamada Y, Yoshida Y, Kiso S, Tsutsui S, Kihara S, Hayashi N, Matsuzawa Y. Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups. J Gastroenterol. 2011 Dec; 46(12): 1361-1367. doi: 10.1007/s00535-011-0453-3.
  34. Shibata R, Takahashi R, Kataoka Y, Ohashi K, Ikeda N, Kihara S, Murohara T, Ouchi N. Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men. Hypertens Res. 2011 Dec; 34(12): 1309-1312. doi: 10.1038/hr.2011.130.
  35. Yamamoto H, Williams EG, Mouchiroud L, Canto C, Fan W, Downes M, Heligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J. NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell. 2011 Nov 11; 147(4): 827-839.
  36. Li P, Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM. Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity. Cell. 2011 Nov 11; 147(4): 815-826.
  37. Beirowski B, Gustin J, Armour SM,Yamamoto H, Viader A, North BJ, Michan S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43): E952-961.
  38. Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 2011 Sep 30; 12(10): 1069-1076.
  39. Yamamoto S, Watabe K, Tsutsui S, Kiso S, Hamasaki T, Kato M, Kamada Y, Yoshida Y, Kihara S, Umeda M, Furubayashi A, Kinoshita K, Kishida O, Fujimoto T, Yamada A, Tsukamoto Y, Hayashi N, Matsuzawa Y. Lower serum level of adiponectin is associated with increased risk of endoscopic erosive gastritis. Dig Dis Sci. 2011 Aug; 56(8): 2354-2360. doi: 10.1007/s10620-011-1681-3.
  40. Hiuge-Shimizu A, Maeda N, Hirata A, Nakatsuji H, Nakamura K, Okuno A, Kihara S, Funahashi T, Shimomura I. Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4): 792-799. doi: 10.1161/ATVBAHA.110.221747.
  41. Bai P, Canto C, Oudart H, Brunyanszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 2011 Apr 6; 13(4): 461-468.
  42. Bai P, Canto C, Brunyanszki A, Huber A, Szanto M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J. PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab. 2011 Apr 6; 13(4): 450-460.
  43. Nakagawa Y, Kishida K, Kihara S, Yoshida R, Funahashi T, Shimomura I. Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue. J Atheroscler Thromb. 2011; 18(3): 240-247.